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Question #45231
The Question
Sertoli cells maintain a highly regulated luminal microenvironment essential for spermatogenesis, contributing to the blood-testis barrier. If a cationic amphipathic antimicrobial peptide inserts into the plasma membrane of a Sertoli cell, which of the following is the most direct physiological consequence?
Options
- A.
Proteolytic degradation of tight junction proteins, leading to the physical separation of adjacent Sertoli cells.
- B.
Formation of unregulated hydrophilic pores that dissipate the transmembrane electrochemical gradient.
- C.
Competitive inhibition of FSH receptors, preventing the synthesis of Androgen Binding Protein (ABP).
- D.
Hyperpolarization of the Sertoli cell membrane due to the active efflux of intracellular cations.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Lipid Amphipathic Nature|Sertoli Cell Functions|Membrane Pore Formation
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Understanding the biophysical mechanism of amphipathic molecules in a lipid bilayer.
Students often assume any 'barrier disruption' implies the enzymatic breakdown of tight junctions (Option A) or hormonal interference (Option C).
The trap relies on failing to connect the term 'amphipathic' with its structural consequence: mimicking membrane lipids while introducing charged channels that destroy ion gradients without requiring enzymatic activity.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Biomolecules - Class 11 |
| Concept | Lipid Amphipathic Nature |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |