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Question #45236
The Question
During an experimental germline gene therapy, a retroviral vector inadvertently inserts into and disrupts the host's DNA methyltransferase (DNMT) gene. Which of the following is the most likely consequence of this disruption on the genomic stability of the resulting offspring?
Options
- A.
Complete suppression of housekeeping genes due to the systemic loss of genomic imprinting.
- B.
Hyperactivation and mobilization of transposable elements due to the absence of cytosine methylation.
- C.
Increased structural stability of the DNA double helix due to the absence of epigenetic methylation on thymine residues.
- D.
Failure of the spliceosome complex to remove introns, as DNA methylation directly dictates the sequence of RNA splicing.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
5-Methylcytosine|Chromatin Remodeling|Gene Therapy
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Connecting epigenetic silencing (DNA methylation) with the suppression of transposable elements (a concept introduced in NCERT's Biotechnology chapter via RNAi).
The primary misconception tested is the specific nitrogenous base targeted by epigenetic methylation (Cytosine vs.
Thymine) and understanding that the most immediate threat of hypomethylation to genomic stability is transposon mobilization, not a failure of basic transcription or splicing machinery.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Biomolecules - Class 11 |
| Concept | Nucleic Acid Structural Stability |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |