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Question #45249
The Question
The transition of a cell from the G0 phase (quiescence) to the G1 phase is strictly regulated. Neoplastic transformation often involves the disruption of this regulation. Which of the following statements regarding this process is INCORRECT?
Options
- A.
Cells in the G0 phase remain metabolically active but do not proliferate unless called upon to do so depending on the requirement of the organism.
- B.
A gain-of-function mutation in a proto-oncogene can force a quiescent cell to bypass regulatory checkpoints and enter constitutive mitosis.
- C.
Proto-oncogenes are normal cellular genes that primarily function to arrest the cell cycle in the G0 phase to prevent tumor formation.
- D.
The loss of contact inhibition in transformed cells prevents them from re-entering the G0 phase, leading to an uncoordinated, neoplastic mass.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
G0 Phase Quiescence|Oncogenes vs Proto-oncogenes|Cell Cycle and Cell Division
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Functional Confusion between Proto-oncogenes and Tumor Suppressor Genes.
Students often mistakenly believe that because proto-oncogenes are 'normal' genes present in healthy cells, their wild-type function is to suppress tumors or arrest the cell cycle.
In reality, they drive the cell cycle forward, and their hyperactivation (gain-of-function) leads to cancer.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell Cycle and Cell Division - Class 11 |
| Concept | G0 Phase Quiescence |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |