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Question #45269
The Question
A targeted chemical inhibitor disrupts the assembly of the synaptonemal complex in the primary spermatocytes of a human male. Which of the following accurately describes the primary meiotic consequence and the subsequent regulatory response within the seminiferous tubule?
Options
- A.
Random segregation of homologous chromosomes during Anaphase I resulting in aneuploid spermatids, which are subsequently phagocytosed by Sertoli cells.
- B.
Failure of sister chromatid separation during Anaphase II resulting in polyploid gametes, which are eliminated by the immunological action of Leydig cells.
- C.
Immediate arrest of the cell cycle at the Zygotene stage, causing primary spermatocytes to revert to diploid spermatogonia via dedifferentiation.
- D.
Unrestricted crossing over during Pachytene leading to chromosomal translocations, with the defective spermatozoa being destroyed by the epididymal epithelium.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Synaptonemal Complex|Sertoli Cell Functions|Human Reproduction
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: This question requires synthesizing Molecular Genetics (Meiosis) with Human Reproduction (Histology).
Students often memorize that the synaptonemal complex is solely for 'crossing over' (Pachytene) but fail to realize its structural necessity for the correct tension and segregation of homologous chromosomes in Anaphase I.
Additionally, it tests the functional distinction between Sertoli cells (phagocytosis/nurse cells) and Leydig cells (endocrine function).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell Cycle and Cell Division - Class 11 |
| Concept | Synaptonemal Complex Assembly |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |