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Question #45444
The Question
A synthetic analog of Parathyroid Hormone (PTH) is designed with a structural modification that significantly extends its plasma half-life. If administered chronically to a normal mammalian model, which of the following physiological outcomes will be observed?
Options
- A.
Sustained osteoclast activation leading to refractory hypercalcemia, overwhelming Thyrocalcitonin (TCT) and causing decreased neuromuscular excitability.
- B.
Enhanced osteoblast proliferation leading to bone hypercalcification, accompanied by tetanic muscle spasms.
- C.
Increased renal excretion of calcium and phosphate, leading to hypocalcemia and hyperphosphatemia.
- D.
Upregulation of Thyrocalcitonin (TCT) receptors on osteoclasts, resulting in a negative feedback loop that completely normalizes blood calcium levels.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
PTH|Thyrocalcitonin|Hormone Half-life Logic
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students frequently confuse the neuromuscular effects of calcium imbalances, associating all parathyroid disorders with 'Tetany' (which is strictly due to hypocalcemia/hypoparathyroidism).
This question requires synthesizing the hypercalcemic role of PTH, the concept of hormone half-life overriding negative feedback (TCT), and the physiological consequence of hypercalcemia (decreased neuromuscular excitability).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Chemical Coordination and Integration - Class 11 |
| Concept | Insulin vs Glucagon Effects |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |