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Question #45457
The Question
A novel autoimmune pathology selectively destroys the Atrial Natriuretic Factor (ANF) receptors located on the afferent arterioles and juxtaglomerular cells. Based on the hormonal regulation of kidney function, which of the following will be the most likely physiological consequence?
Options
- A.
Chronic systemic hypertension due to the loss of the antagonistic vasodilatory check on the Renin-Angiotensin mechanism.
- B.
Severe diuresis and hyponatremia due to the uninhibited hypersecretion of Aldosterone from the adrenal cortex.
- C.
A drastic fall in Glomerular Filtration Rate (GFR) caused by the permanent, uninhibited vasodilation of the afferent arteriole.
- D.
Complete cessation of ANF synthesis by the atrial myocytes due to a negative feedback loop from the destroyed renal receptors.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Autoimmunity Principles|ANF|RAAS
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: The antagonistic feedback loop between the heart (ANF) and the kidney (RAAS).
The trap lies in distinguishing between hormone deficiency and receptor destruction.
Students might choose D assuming a standard negative feedback loop, or B by confusing the actual function of Aldosterone (retention vs. excretion).
The core NCERT concept tested is that ANF is the primary physiological 'check' on RAAS-induced hypertension.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Chemical Coordination and Integration - Class 11 |
| Concept | Atrial Natriuretic Factor (ANF) |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |