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Question #45523
The Question
A 42-year-old pregnant woman is advised to undergo amniocentesis due to the increased risk of chromosomal aneuploidy associated with advanced maternal age. Which of the following statements regarding the biological basis, utility, and constraints of this procedure is INCORRECT?
Options
- A.
The increased risk of aneuploidy is primarily due to nondisjunction errors in primary oocytes that have been arrested in the diplotene stage of prophase I for decades.
- B.
The procedure relies on the karyotypic analysis of fetal cells shed into the amniotic fluid to detect disorders like Trisomy 21 or Klinefelter's syndrome.
- C.
It can be legally and effectively utilized to screen for specific phenotypic traits governed by multiple allelism to facilitate therapeutic eugenic selection.
- D.
In addition to chromosomal aberrations, it can detect specific Mendelian disorders such as haemophilia and sickle-cell anemia using biochemical or molecular markers.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Amniocentesis Ethical Constraint|Spermatogenesis vs. Oogenesis Chronology|Multiple Allelism Limitation
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often confuse the diagnostic resolution of karyotyping (which detects gross chromosomal aneuploidies) with molecular genotyping (which detects allelic variations).
The trap also tests the integration of legal/ethical constraints (PNDT Act) mentioned in NCERT, forcing the student to distinguish between legal therapeutic screening for severe diseases and illegal eugenic selection for complex phenotypic traits.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Reproductive Health - Class 12 |
| Concept | Amniocentesis Ethical Constraint |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |