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Question #45542
The Question
A 28-year-old female diagnosed with Rheumatoid arthritis is advised caution by her gynecologist when considering a Copper-releasing Intrauterine Device (IUD) for contraception. Based on the physiological mechanism of IUDs and the principles of autoimmunity, which of the following statements best explains the rationale behind this medical advice?
Options
- A.
Copper ions systemically suppress the cell-mediated immune response, leading to a complete failure of self-tolerance and rapid joint degeneration.
- B.
The IUD functions by inducing localized chronic inflammation and leukocyte infiltration, which may act as a trigger to exacerbate her pre-existing systemic autoimmune pathology.
- C.
Phagocytosis of sperms by macrophages in the uterus directly generates rheumatoid factors, leading to severe systemic joint inflammation.
- D.
Copper-releasing IUDs inhibit the release of local cytokines, thereby masking the symptoms of Rheumatoid arthritis and delaying necessary treatment.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
IUDs|Autoimmunity Principles|Leukocyte Infiltration
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often memorize the NCERT line 'IUDs increase phagocytosis of sperms' without recognizing that this is fundamentally an inflammatory immune response.
The question tests the ability to synthesize Reproductive Health (mechanism of IUDs) with Human Health and Disease (autoimmunity and inflammation), requiring the student to distinguish between targeted local inflammation for contraception and generalized autoimmune pathology.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Reproductive Health - Class 12 |
| Concept | IUD Physiological Mechanism |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |