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Question #45566
The Question
A sterile female with a normal uterine environment and patent fallopian tubes opts for Assisted Reproductive Technology using a donor ovum. However, the donor is suspected of having a high frequency of meiotic non-disjunction. Why would a clinician specifically advise against Gamete Intrafallopian Transfer (GIFT) in favor of In Vitro Fertilization (IVF) for this patient?
Options
- A.
GIFT facilitates in vivo fertilization, thereby preventing pre-implantation genetic diagnosis of the resulting embryo for aneuploidy.
- B.
GIFT involves the transfer of an early embryo into the fallopian tube, where aneuploid embryos are selectively rejected by the mucosal lining.
- C.
Aneuploid gametes transferred during GIFT cannot undergo syngamy in the ampullary region due to altered zona pellucida receptors.
- D.
The in vitro conditions of GIFT increase the risk of polyspermy, leading to polyploidy rather than aneuploidy.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
GIFT|Aneuploidy|Non-disjunction
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Distinguishing between in vivo (GIFT) and in vitro (IVF/ZIFT) fertilization locations and understanding how this physical location dictates the feasibility of genetic screening.
Students often memorize ART acronyms without visualizing the anatomical site of fertilization, failing to realize that in vivo fertilization completely bypasses the opportunity to screen the resulting zygote/embryo before implantation.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Reproductive Health - Class 12 |
| Concept | GIFT Applicability |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |