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Question #45711
The Question
A patient with systemic inflammation develops uremia. Diagnostic evaluation using ELISA confirms the presence of circulating immune complexes. Renal biopsy reveals that these complexes have physically obstructed the slit pores located in the visceral layer of the Bowman's capsule. Which of the following represents the most accurate physiological consequence of this obstruction and the underlying principle of the diagnostic test used?
Options
- A.
A decrease in the Glomerular Filtration Fraction; the diagnostic test is based on antigen-antibody interactions.
- B.
An increase in the Glomerular Filtration Rate due to compensatory hydrostatic pressure; the diagnostic test detects amplified pathogenic DNA.
- C.
A primary decrease in Renal Plasma Flow with an unchanged Filtration Fraction; the diagnostic test utilizes enzyme-substrate reactions to detect nucleic acids.
- D.
An increase in the Glomerular Filtration Fraction due to efferent arteriole constriction; the diagnostic test is based on antigen-antibody interactions.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Glomerular Filtration Fraction|Molecular Diagnosis by ELISA|Antibody Structure Logic
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: This question tests the synthesis of three distinct NCERT concepts: the structural anatomy of the filtration membrane (Excretory Products), the mathematical relationship of renal hemodynamics (FF = GFR/RPF), and the molecular diagnostic principle of ELISA (Biotechnology/Human Health).
The common misconception is confusing the diagnostic principles of ELISA with PCR, and failing to deduce that a physical barrier obstruction specifically lowers GFR, thereby lowering the Filtration Fraction.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Excretory Products and Their Elimination - Class 11 |
| Concept | Glomerular Filtration Fraction |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |