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Question #45726
The Question
A patient experiencing severe volume depletion (hypotension) is administered a pharmacological drug that inhibits Angiotensin Converting Enzyme (ACE). Which of the following best explains the subsequent sharp decline observed in their Glomerular Filtration Rate (GFR)?
Options
- A.
Dilation of the efferent arteriole due to the absence of Angiotensin II, reducing glomerular hydrostatic pressure.
- B.
Intense vasoconstriction of the afferent arteriole caused by the systemic accumulation of Renin from JG cells.
- C.
Immediate cessation of conditional sodium reabsorption in the proximal convoluted tubule due to Aldosterone blockade.
- D.
Failure of the macula densa to detect low tubular fluid flow, leading to an upstream halt in the RAAS cascade.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
ACE_Inhibitors|Angiotensin_Receptor_Blockers|Homeostasis
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Understanding the structure-function coupling of the nephron's blood supply.
Students often memorize that RAAS increases blood pressure systemically, but fail to realize that intra-renally, Angiotensin II specifically targets the efferent arteriole to maintain GFR.
Furthermore, students frequently fall for the 'Location Trap' in Option C, confusing the site of Aldosterone action (DCT) with the PCT.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Excretory Products and Their Elimination - Class 11 |
| Concept | RAAS Pathway Feedback Loop |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |