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Question #45797
The Question
Rheumatoid arthritis (RA) and age-related osteoporosis are skeletal disorders that ultimately compromise bone integrity, yet their pathogenesis involving calcium dynamics and cellular mediators differs significantly. Which of the following statements regarding these disorders is INCORRECT?
Options
- A.
RA is initiated by autoimmune inflammation of the synovial membrane, whereas osteoporosis is a systemic metabolic disorder characterized by a generalized decrease in bone mass.
- B.
In chronic RA, an inflammatory cytokine storm locally stimulates RANKL expression, which hyperactivates osteoclasts and leads to erosive bone loss at the joint.
- C.
Both conditions involve aberrant osteoclast activity, but osteoporosis is primarily driven by the systemic withdrawal of estrogen's inhibitory effect on osteoclasts.
- D.
The localized bone destruction in RA is a direct result of inflammatory cytokines stimulating osteoblasts to rapidly mineralize the synovial fluid, causing mechanical friction.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Hydroxyapatite|Osteoclasts|TNF-alpha
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Confusing the cellular mediators of bone destruction.
Students often misinterpret the formation of 'pannus' (inflamed synovial tissue) in RA as abnormal bone mineralization by osteoblasts.
The trap relies on functional inversion: attributing bone erosion to osteoblast-mediated calcification rather than cytokine-driven osteoclast hyperactivation.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Locomotion and Movement - Class 11 |
| Concept | Calcium Dynamics |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |