Before You Begin
Question #45804
The Question
Severe systemic lactic acidosis, often a consequence of extreme muscle fatigue or metabolic disorders, can lead to meiotic arrest during spermatogenesis. Based on the physiological roles of testicular cells, which of the following mechanisms best explains this phenomenon?
Options
- A.
Acidosis disrupts the tight junctions of Sertoli cells, compromising the Blood-Testis Barrier and the metabolic microenvironment required for spermatocytes.
- B.
High systemic lactic acid competitively inhibits the binding of Follicle Stimulating Hormone (FSH) to Leydig cells, preventing meiotic progression.
- C.
Lactic acid accumulation directly triggers the premature release of hydrolytic enzymes from the acrosome, destroying primary spermatocytes.
- D.
Acidosis inhibits the secretion of androgens by the Sertoli cells, which is strictly essential for the completion of the second meiotic division.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Sertoli_Cell_Functions|pH_Sensitivity|Lactate_Dehydrogenase
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Integrating systemic metabolic states (lactic acidosis) with reproductive microanatomy (Blood-Testis Barrier).
The distractors rely on 'Functional Confusion' traps—specifically swapping the target cells for gonadotropins (FSH/LH) and the source cells for androgens (Leydig vs.
Sertoli), which are high-frequency errors among NEET aspirants.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Locomotion and Movement - Class 11 |
| Concept | Muscle Fatigue Factors |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |