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Question #45889
The Question
Following the integration of the HIV genome into the DNA of a human macrophage, the host cell acts as an 'HIV factory'. Which of the following statements regarding the subsequent synthesis of new viral genomes and proteins is INCORRECT?
Options
- A.
The host's DNA-dependent RNA polymerase recognizes the proviral promoter and initiates transcription.
- B.
The newly synthesized viral RNA serves both as mRNA for viral protein translation and as the genomic RNA for progeny virions.
- C.
The host's RNA polymerase utilizes the 5' to 3' coding strand of the integrated viral DNA as a template to synthesize viral RNA.
- D.
The integrated provirus becomes a permanent part of the host macrophage genome, ensuring continuous viral production without immediate cell lysis.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Evolutionary_Exception
Tackle problems where standard rules evolve or change based on specific environmental constraints.
Concepts Behind This Question
HIV Replication Cycle|Reverse Transcriptase|Viral DNA
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Integrating Chapter 8 (Human Health) with Chapter 6 (Molecular Basis of Inheritance).
Students often memorize the HIV lifecycle but fail to apply the strict rules of standard transcription to the provirus.
The trap exploits the nomenclature of DNA strands: because the 'coding strand' has the same sequence as the resulting viral mRNA, students mistakenly assume it serves as the physical template, forgetting that RNA polymerase requires a 3' to 5' template strand.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Molecular Basis of Inheritance - Class 12 |
| Concept | Non-Coding Strand Utility |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |