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Question #46338
The Question
During the malignant transformation of alveolar tissue in pulmonary adenocarcinoma, cellular dedifferentiation redirects lipid metabolism and utilizes endogenous RNA interference (RNAi) to silence genes responsible for surfactant protein synthesis. Based on NCERT principles of respiratory physiology and molecular genetics, which of the following is the most likely consequence of this specific molecular event?
Options
- A.
Type I pneumocytes fail to synthesize lecithin, leading to increased alveolar surface tension and atelectasis.
- B.
Type II pneumocytes lose their ability to secrete phospholipid-rich surfactant, resulting in decreased lung compliance and alveolar collapse.
- C.
The RNAi-mediated transcriptional silencing of surfactant genes prevents the formation of the respiratory membrane's basement substance.
- D.
The redirection of lipid metabolism increases the secretion of dipalmitoylphosphatidylcholine, causing pulmonary fibrosis.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Surfactant Function|RNA Interference (RNAi) Mechanism|Oncogenes vs Proto-oncogenes
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: This question tests the student's ability to synthesize molecular genetics with human physiology.
The primary trap relies on Functional Overlap and Location Specificity: students frequently confuse the roles of Type I (diffusion) and Type II (secretion) pneumocytes.
A secondary trap tests the precise NCERT definition of RNAi, which is strictly a post-transcriptional (not transcriptional) silencing mechanism.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Breathing and Exchange of Gases - Class 11 |
| Concept | Surfactant Function |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |