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Question #46394
The Question
A patient with severe hyperthyroidism (thyrotoxicosis) is observed to have a prolonged blood clotting time, despite having normal platelet counts, normal serum calcium levels, and adequate Vitamin K intake. Based on the physiological roles of the liver and thyroid gland, which of the following best explains this sub-clinical coagulopathy?
Options
- A.
Accelerated catabolism of plasma clotting factors due to a hypermetabolic state outpaces their hepatic synthesis.
- B.
Excess thyroxine directly inhibits the release of thrombokinase from injured tissues and platelets.
- C.
High thyroid activity suppresses the gamma-carboxylation of prothrombin by antagonizing Vitamin K.
- D.
Increased basal metabolic rate shifts liver metabolism exclusively towards gluconeogenesis, halting all plasma protein synthesis.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Vitamin K|Prothrombin|Thyroxine
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Integrating the endocrine function of the thyroid (BMR and protein turnover) with the hepatic synthesis of clotting factors.
The trap relies on students isolating physiological systems—failing to recognize that a systemic hypermetabolic state accelerates the degradation of all plasma proteins, thereby bridging endocrinology with hematology.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Body Fluids and Circulation - Class 11 |
| Concept | Clotting Cascade Factors |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |