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Question #46515
The Question
During an active infection in the Mucosa-Associated Lymphoid Tissue (MALT), a specific viral toxin impairs the proofreading fidelity of aminoacyl-tRNA synthetases in activated B-lymphocytes. Which of the following statements correctly predicts the direct biochemical and immunological consequence of this impairment?
Options
- A.
Polypeptide synthesis ceases immediately due to the unavailability of charged tRNAs, leading to a complete absence of immunoglobulins in the MALT.
- B.
Immunoglobulins are synthesized with altered primary structures, disrupting disulfide bond positioning and rendering the paratopes incapable of antigen recognition.
- C.
Memory B-cells fail to undergo clonal expansion because the translation of cell-surface B-cell receptors (BCRs) is prematurely terminated at the ribosome.
- D.
The synthesized antibodies will retain antigen specificity but fail to undergo genetic class switching from IgM to IgA, compromising mucosal immunity.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
MALT Structure|tRNA Charging Accuracy|Antibody Structure Logic
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often confuse the 'inhibition of an enzyme's activity' (which stops a process) with the 'loss of an enzyme's fidelity/proofreading' (which allows the process to continue but produces a faulty product).
This question requires synthesizing the Central Dogma (translation errors) with structural immunology (paratope conformation via disulfide bonds), testing high-order application of NCERT concepts.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Human Health and Disease - Class 12 |
| Concept | MALT Structure |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |