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Question #46517
The Question
In a patient suffering from advanced AIDS, there is a marked failure to produce adequate antibodies against opportunistic infections, despite the patient possessing structurally intact B-lymphocytes. Which of the following best explains the primary physiological reason for this humoral immunodeficiency?
Options
- A.
HIV directly infects and destroys B-lymphocytes, preventing the assembly of H2L2 immunoglobulin structures.
- B.
The progressive decrease in T-helper lymphocytes removes the essential stimulation required for B-lymphocyte activation and antibody production.
- C.
The viral genome integrates into the host B-cell DNA, suppressing the transcription of immunoglobulin genes.
- D.
The depletion of Cytotoxic T-cells (Tc) prevents the direct presentation of antigens to B-lymphocytes for the humoral response.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
IgG_Structure|CD4_Receptors|Reverse_Transcriptase
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often confuse the effector of humoral immunity (B-cells) with its regulator (T-helper cells).
The common misconception is assuming that a lack of antibodies implies direct viral destruction of B-cells.
This question tests the NCERT-based understanding that HIV's destruction of cell-mediated regulators (CD4+ TH cells) indirectly causes the collapse of the humoral response.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Human Health and Disease - Class 12 |
| Concept | Antibody Structure Logic |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |