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Question #46533
The Question
During the HIV replication cycle, viral DNA integrates into the host genome as a provirus. The persistent expression of viral proteins on the host cell surface can trigger an autoimmune-like destruction of immune cells. Which of the following statements is INCORRECT regarding the immunological principles underlying this phenomenon?
Options
- A.
Infected host cells present processed viral peptides via the MHC-I pathway, marking themselves for destruction by Cytotoxic T-lymphocytes.
- B.
Structural similarities between HIV envelope glycoproteins and host self-antigens can lead to the destruction of uninfected cells through molecular mimicry.
- C.
The continuous production of viruses by surviving macrophages suppresses bystander activation, thereby strictly maintaining peripheral T-cell tolerance.
- D.
The integration of the provirus and subsequent viral protein expression alters the host cell's surface profile, causing a failure in self vs. non-self discrimination.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Provirus|Host_Genome|Autoimmunity
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often misunderstand the role of macrophages in HIV (they survive and act as factories) and how chronic infection affects immune tolerance.
The trap lies in assuming that because macrophages survive, they maintain immune homeostasis.
In reality, their continuous viral shedding drives chronic inflammation, bystander activation, and the breakdown of self-tolerance, leading to autoimmune-like pathologies.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Human Health and Disease - Class 12 |
| Concept | HIV Replication Cycle |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |