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Question #46722
The Question
A novel experimental toxin specifically binds to and sequesters the 60S ribosomal subunit in the follicular cells of the human thyroid gland. Which of the following represents the most accurate sequence of physiological consequences in a subject exposed to this toxin?
Options
- A.
Arrest of 70S monosome formation → Cessation of thyroglobulin synthesis → Decline in T3/T4 levels → Hyposecretion of TSH
- B.
Arrest of 80S monosome formation → Accumulation of thyroglobulin in the follicular lumen → Decline in T3/T4 levels → Hypersecretion of TSH
- C.
Arrest of 80S monosome formation → Cessation of thyroglobulin synthesis → Decline in T3/T4 levels → Hypersecretion of TSH
- D.
Arrest of 80S monosome formation → Cessation of thyroglobulin synthesis → Elevation in T3/T4 levels → Suppression of TSH
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Ribosome Svedberg Coefficient|Thyroid Hormone Synthesis|Hormonal Feedback Loops
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Integrating Cell Biology (80S eukaryotic ribosome assembly) with Chemical Coordination (proteinaceous nature of thyroglobulin and negative feedback loops).
The trap relies on students either missing the 80S vs 70S distinction (Option A) or failing to realize that blocking translation prevents the protein scaffold (thyroglobulin) from ever reaching the lumen (Option B), ultimately triggering the classic primary hypothyroidism feedback response (high TSH).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell – The Unit of Life - Class 11 |
| Concept | Ribosome Svedberg Coefficient |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |