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Question #46730
The Question
A pharmacological agent specifically inhibits the Sodium-Glucose Linked Transporters (SGLT2) located in the Proximal Convoluted Tubule (PCT). Which of the following represents the most accurate sequence of downstream physiological consequences?
Options
- A.
Retention of glucose in the filtrate increases tubular osmolarity, inducing osmotic diuresis which increases tubular flow rate and impairs the counter-current multiplier mechanism, leading to polyuria.
- B.
Enhanced passive reabsorption of water in the descending limb of Henle's loop due to the hypertonic filtrate, resulting in the formation of highly concentrated urine.
- C.
Immediate suppression of ADH release from the neurohypophysis due to the hyperosmolar filtrate, leading to decreased facultative water reabsorption in the DCT.
- D.
Active secretion of excess glucose into the Distal Convoluted Tubule (DCT) to maintain blood glucose homeostasis, leading to obligatory water loss and polyuria.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Renal Threshold Concept|Counter-Current Mechanism Multiplier
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often memorize that the PCT reabsorbs glucose but fail to link the failure of this reabsorption to the physical principles of osmosis (osmotic diuresis).
The trap lies in misunderstanding the location of the hypertonicity; a hypertonic filtrate inside the tubule holds onto water, disrupting the downstream counter-current multiplier and causing polyuria, rather than concentrating the urine.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell – The Unit of Life - Class 11 |
| Concept | Active vs Passive Gradient Logic |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |