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Question #46735
The Question
In a rare genetic disorder, a mutation prevents the Golgi apparatus from adding a specific carbohydrate marker (Mannose-6-phosphate) to newly synthesized acid hydrolases. Based on the functional logistics of the endomembrane system, which of the following represents the most likely fate of these enzymes?
Options
- A.
They will be routed to the lysosomes but fail to function due to the absence of an activating phosphorylation cascade.
- B.
They will be constitutively secreted outside the cell via exocytotic transport vesicles.
- C.
They will accumulate in the cis-Golgi network, eventually leading to Golgi fragmentation and cellular apoptosis.
- D.
They will be retrogradely transported back to the Rough Endoplasmic Reticulum for degradation.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Mannose-6-Phosphate_Tagging|Lysosomes|Hydrolases
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Understanding that the default pathway for proteins passing through the Golgi apparatus is extracellular secretion.
Specific tags (like M6P) are required to actively divert proteins to intracellular targets like lysosomes.
Common Misconception: Students often assume that a failure in Golgi tagging leads to intracellular accumulation, ER stress, or immediate degradation, failing to realize that the constitutive secretory pathway acts as the default 'exit' route for untagged proteins.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell – The Unit of Life - Class 11 |
| Concept | Endomembrane System Connectivity |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |