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Question #46744
The Question
Lysosomes contain a variety of hydrolytic enzymes that are optimally active at an acidic pH. A researcher treats a culture of post-mitotic neural cells with chloroquine, a weak base that diffuses into organelles and becomes protonated. Which of the following will be the most direct consequence of this treatment?
Options
- A.
Enhanced degradation of cellular debris due to the hyperactivation of V-type ATPases.
- B.
Accumulation of autophagosomes and failure to clear misfolded proteins due to increased lysosomal pH.
- C.
Immediate rupture of the lysosomal membrane, leading to autolysis of the neural cells.
- D.
Cessation of acid hydrolase synthesis at the rough endoplasmic reticulum.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
V-type_H+-ATPase|Acid_Hydrolases|Secondary_Protein_Structure_Stabilizers
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often over-extrapolate the NCERT 'suicide bag' concept, assuming any lysosomal stress causes membrane rupture and autolysis (Option C).
This question tests the precise understanding that lysosomal enzyme activity is strictly pH-dependent.
A weak base neutralizes this pH, leading to functional inhibition (autophagic failure) rather than structural rupture.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell – The Unit of Life - Class 11 |
| Concept | Lysosomal pH Homeostasis |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |