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Question #46854
The Question
In a patient suffering from chronic allergic inflammation, a biopsy of the areolar connective tissue reveals significant edema and localized degradation of collagen and elastin fibers. Which of the following accurately describes the mechanism linking the resident cells of this tissue to the observed pathology?
Options
- A.
Mast cells undergo IgE-mediated degranulation, releasing histamine which increases vascular permeability, and proteases which degrade the extracellular matrix.
- B.
Fibroblasts are stimulated by IgE to release histamine for vasodilation and secrete collagenase to remodel the connective tissue matrix.
- C.
Macrophages phagocytose the allergen and release serotonin to induce edema, while directly degrading the elastin fibers via lysosomal enzymes.
- D.
Histamine released by mast cells directly cleaves the peptide bonds of collagen fibers, while simultaneously increasing capillary permeability to cause edema.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Areolar_Connective_Tissue|Histamine|Collagenase_Release
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Integrating Class 11 Structural Organisation (Areolar tissue composition) with Class 12 Human Health (Allergy mechanism).
The trap lies in functional misattribution-students often memorize 'histamine causes allergy symptoms' but incorrectly assume histamine itself degrades the tissue (Option D), or they confuse the specific roles of resident areolar cells like fibroblasts and macrophages (Options B and C).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Structural Organisation in Animals - Class 11 |
| Concept | Connective Tissue Fiber Composition |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |