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Question #46855
The Question
Tissue repair following an acute injury aims to restore the metabolic steady state. However, chronic inflammation can disrupt this homeostasis, leading to fibrosis rather than true regeneration. Which of the following best explains the cellular and structural basis of this fibrotic transition?
Options
- A.
Fibroblasts transition into contractile myofibroblasts, excessively depositing Type I collagen that replaces functional parenchyma.
- B.
Chondrocytes dedifferentiate into fibroblasts, secreting excess elastin to form a flexible but non-functional scar.
- C.
Mast cells over-secrete histamine, which directly polymerizes fibrinogen into a permanent dense regular connective tissue.
- D.
Epithelial cells undergo apoptosis, allowing loose areolar connective tissue to hyper-proliferate and completely restore organ function.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Fibroblasts|Collagen_Type_I|Myofibroblasts
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Distinguishing between true regeneration (restoring functional parenchyma) and fibrosis (replacement by non-functional connective tissue scar).
The trap relies on functional confusion among connective tissue cells (mast cells vs. fibroblasts) and misunderstanding the structural composition of scar tissue (Type I collagen vs. elastin).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Structural Organisation in Animals - Class 11 |
| Concept | Connective Tissue Fiber Composition |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |