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Question #46861
The Question
A patient with severe glomerular damage exhibits massive loss of plasma albumins in urine, leading to systemic swelling and profound skeletal muscle weakness. Which of the following best explains the physiological sequence linking this renal pathology to the impairment of skeletal muscle contraction?
Options
- A.
Decreased blood colloidal osmotic pressure causes interstitial edema, which increases the diffusion barrier between capillaries and the sarcolemma, disrupting localized ionic gradients essential for excitation-contraction coupling.
- B.
Decreased blood colloidal osmotic pressure causes intracellular edema within the sarcoplasmic reticulum, diluting the stored Ca2+ and preventing its binding to the troponin subunit.
- C.
Hypoproteinemia increases blood colloidal osmotic pressure, drawing fluid out of the muscle fibers, causing dehydration that inhibits the ATPase activity of the myosin head.
- D.
The loss of plasma albumins directly reduces the oxygen-carrying capacity of blood, forcing muscle fibers into anaerobic respiration and causing lactic acid-induced fatigue.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Skeletal Muscle Striation Pattern|Plasma Proteins and Osmotic Pressure|Sarcomere|Calcium ions
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Integrating Excretory System pathology (proteinuria) with Body Fluids (osmotic pressure) and Locomotion (excitation-contraction coupling).
The trap relies on Functional Confusion (confusing albumin's role with hemoglobin's role in Option D) and Location Specificity (interstitial vs. intracellular edema in Option B).
Students must understand that systemic fluid shifts mechanically and ionically disrupt the micro-environment of the sarcolemma.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Structural Organisation in Animals - Class 11 |
| Concept | Skeletal Muscle Striation Pattern |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |